The Penn-McKee hotel was opened in 1926 and quickly became the place for weddings, club meetings, and a variety of special events. It has a particularly rich history in relation to important US citizens and presidents. Harry Truman dined there during his 1944 Vice Presidential campaign, and the first time John F Kennedy and Richard Nixon debated, long before they were well known outside of their constituencies, was at the Penn-McKee hotel on April 22, 1947. (http://blog.nixonfoundation.org/2010/06/can-the-penn-mckee-hotel-be-saved/
Besides hosting future presidents, it was considered the nicest hotel in McKeesport. The building ceased being a hotel in 1980, and operated as a nursing home until 1992. Various preservation groups appear to be fighting over the building and it's future.